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Publications

 

2017


  1. Wei Han, Shraddha Sapkota, Richard Camicioli, Roger A. Dixon, Liang Li, 2017, ” Profiling Novel Metabolic Biomarkers for Parkinson’s Disease Using In-depth Metabolomic Analysis”, Movement Disorders, in press.
  2. Deying Chen, Wei Han, Xiaoling Su, Liang Li*, and Lanjuan Li*, 2017, “Overcoming Sample Matrix Effect in Quantitative Blood Metabolomics Using Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry”, Anal. Chem. in press.
  3. Jinfeng Yang, Nan Wang, Deying Chen, Jiong Yu, Qiaoling Pan, Dan Wang, Jingqi Liu, Xiaowei Shi, Xiaotian Dong, Hongcui Cao, Liang Li, and Lan Juan Li, 2017, “The impact of GFP reporter gene transduction and expression on metabolomics of placental mesenchymal stem cells determined by UHPLC-Q/TOF-MS”, Stem Cells International, in press.
  4. Kevin Hooton and Liang Li, 2017, “Non-occlusive Sweat Collection Combined with Chemical Isotope Labeling LC-MS for Human Sweat Metabolomics and Mapping the Sweat Metabolomes at Different Skin Locations”, Anal. Chem. 89, 7847-7851. (Open Access Article)
  5. Shuang Zhao, Margot Dawe, Kevin Guo and Liang Li, 2017, “Development of High-Performance Chemical Isotope Labeling LC-MS for Profiling the Carbonyl Submetabolome”, Anal. Chem. 89, 6758-6765. (Open Access Article)
  6. Michael C. Schultz, Jian Zhang, Xian Luo, Olekesandra Savchenko, Liang Li, Michael Deyholos and Jie Chen, 2017, “Impact of Low-intensity Pulsed Ultrasound on Transcript and Metabolite Abundance in Saccharomyces cerevisiae”, J Proteome Res. 16, 2975-2982.
  7. Wei Han and Liang Li, 2017, “Chemical Isotope Labeling LC-MS for Human Blood Metabolome Analysis”, in Clinical Metabolomics: Methods and Protocols., Martin Giera, Ed.; Springer, New York; Chapter 3.1.14: 14 pages.
  8. Dorothea Mung and Liang Li, 2017, “Development of Chemical Isotope Labeling LC-MS for Milk Metabolomics: Comprehensive and Quantitative Profiling of the Amine/Phenol Submetabolome”, Anal. Chem. 89, 4435-4443.
  9. Lina Yao, Hui Shen, Nan Wang, Jaspaul Tatlay, Liang Li, Tin Wee Tan and Yuan Kun Lee, 2017, “Elevated acetyl-CoA by amino acid recycling fuels microalgal neutral lipid accumulation in exponential growth phase for biofuel production”, Plant Biotechnology, 15, 497-509.
  10. Deying Chen, Xiaoling Su, Nan Wang, Yunong Li, Hua Yin, Liang Li* and Lanjuan Li*, 2017, “Chemical Isotope Labeling LC-MS for Monitoring Disease Progression and Treatment in Animal Models: Plasma Metabolomics Study of Osteoarthritis Rat Model”, Scientific Reports, 7, 40543; doi: 10.1038/srep40543. (Open Access Article)

    2016


  11. Yiman Wu, Femke Streijger, Yining Wang, Guohui Lin, Sean Christie, Jean-Marc Mac-Thiong, Stefan Parent, Christopher S. Bailey, Scott Paquette, Michael C. Boyd, Tamir Ailon, John Street, Charles G. Fisher, Marcel F. Dvorak, Brian K. Kwon* and Liang Li*, 2016, “Parallel Metabolomic Profiling of Cerebrospinal Fluid and Serum for Identifying Biomarkers of Injury Severity after Acute Human Spinal Cord Injury”, Scientific Reports, 6, 38718; doi: 10.1038/srep38718. (Open Access Article)
  12. Shuang Zhao, Xian Luo and Liang Li, 2016, “Chemical Isotope Labeling LC-MS for High Coverage and Quantitative Profiling of the Hydroxyl Submetabolome in Metabolomics”, Anal. Chem. 88, 10617-10623. (Open Access Article)
  13. Tao Huan†, Jia Wen Xian†, Wing Nang Leung, Liang Li* and Chun Wai Chan*, 2016, “Cerebrospinal Fluid Metabolomics After Natural Product Treatment in an Experimental Model of Cerebral Ischemia”, OMICS A Journal of Integrative Biology, 20, 670-680.
  14. Xiuju Li, Aruna Augustine, Difei Sun, Liang Li and Larry Fliegel, 2016, “Activation of the Na+/H+ exchanger in isolated cardiomyocytes through β-Raf dependent pathways. Role of Thr653 of the cytosolic tail”, Journal of Molecular and Cellular Cardiology, 99, 65-75.
  15. Tao Huan, Dean A. Troyer and Liang Li, 2016, “Metabolite Analysis and Histology on the Exact Same Tissue: Comprehensive Metabolomic Profiling and Metabolic Classification of Prostate Cancer”, Scientific Reports, 6, 32272; doi:10.1038/srep32272. (Open Access Article)
  16. Kevin Hooton, Wei Han and Liang Li, 2016, “Comprehensive and Quantitative Profiling of the Human Sweat Submetabolome Using High-Performance Chemical Isotope Labeling LC-MS”, Anal. Chem. 88, 7378-7386.
  17. Weifeng Shen, Wei Han, Yunong Li, Zhiqi Meng, Leiming Cai and Liang Li, 2016, “Development of Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry for Silkworm Hemolymph Metabolomics”, Anal. Chim. Acta. 942, 1-11. (Cover Article)
  18. Xian Luo, Shuang Zhao, Tao Huan, Difei Sun, R. Magnus N. Friis, Michael C. Schultz and Liang Li, 2016, “High-Performance Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry for Profiling the Metabolomic Reprogramming Elicited by Ammonium Limitation in Yeast”, J Proteome Res, 15, 1602-1612.
  19. Francois V. Bolduc, Amanda Lau, Cory S. Rosenfelt, Steven Langer, Nan Wang, Lisa Smithson, Diana Lefebvre, R. Todd Alexander, Clayton T. Dickson, Liang Li, Allan B. Becker, Padmaja Subbarao, Stuart E. Turvey, Jacqueline Pei, Malcolm R. Sears, Piush J. Mandhane for the CHILD Study Investigators, 2016, “Cognitive enhancement in infants associated with increased maternal fruit intake during pregnancy: results from a birth cohort study with validation in an animal model”, EBioMedicine, 8, 331-340.
  20. David Achaintre, Audrey Buleté, Cécile Cren-Olivé, Liang Li, Sabina Rinaldi, Augustin Scalbert, 2016, “Differential Isotope Labelling of 38 Dietary Polyphenols and their Quantification in Urine by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry”, Anal. Chem. 88, 2637-2644.
  21. Liang Li, Nan Wang, Deying Chen, Xiaoling Su and Jing Jiang, 2016, “Proteomics Research in Infectious Disease”, in Infectious Disease, Lanjuan Li, Ed.; China People’s Health Publishing House, Beijing; Chapter 21, 34 pages.
  22. Yiman Wu and Liang Li, 2016, “Sample Normalization Methods in Quantitative Metabolomics”, J Chromatogr. A, 1430, 80-95. (Editors’ Choice Review)
  23. Xiaoling Su, Nan Wang, Deying Chen, Yunong Li, Yingfeng Lu, Tao Huan, Wei Xu, Liang Li* and Lanjuan Li*, 2016, “Dansylation Isotope Labeling Liquid Chromatography Mass Spectrometry for Parallel Profiling of Human Urinary and Fecal Submetabolomes”, Anal. Chim. Acta. 903, 100-109.
  24. Hind Alqahtani, Nidhi Gupta, Karen Jung, Keshav Gopal, Abdulraheem Alshareef, Xiaoxia Ye, Fang Wu, Liang Li and Raymond Lai, 2016, “DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer”, Cellular Signalling, 28, 42-50.

    2015


  25. Zhendong Li, Jaspaul Tatlay and Liang Li, 2015, “Nanoflow LC-MS for High-Performance Chemical Isotope Labeling Quantitative Metabolomics”, Anal. Chem. 87, 11468-11474.
  26. Tao Huan, Chenqu Tang, Ronghong Li, Yi Shi, Guohui Li and Liang Li, 2015, “MyCompoundID MS/MS Search: Metabolite Identification Using a Library of Predicted Fragment-Ion-Spectra of 383,830 Possible Human Metabolites”, Anal. Chem. 87, 10619-10626. (Open Access Article)
  27. Tao Huan, Yiman Wu, Chenqu Tang, Guohui Lin and Liang Li, 2015, “DnsID in MyCompoundID for Rapid Identification of Dansylated Amine- and Phenol-Containing Metabolites in LC-MS-Based Metabolomics”, Anal. Chem. 87, 9838–9845.
  28. Wei Han and Liang Li, 2015, “Matrix Effect on Chemical Isotope Labeling and Its Implication in Metabolomic Sample Preparation for Quantitative Metabolomics”, Metabolomics, 11, 1733-1742.
  29. Tao Huan and Liang Li, 2015, “Quantitative Metabolome Analysis Based on Chromatographic Peak Reconstruction in Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry”, Anal. Chem. 87, 7011-7016.
  30. Ruokun Zhou, Tao Huan and Liang Li, 2015, “Development of Versatile Isotopic Labeling Reagents for Profiling the Amine Submetabolome by Liquid Chromatography Mass Spectrometry”, Anal. Chim. Acta. 881, 107-116.
  31. Kathleen Bone, Peng Wang, Fang Wu, Chengsheng Wu, Liang Li, Julinor Bacani, and Susan Andrew and Raymond Lai, 2015, “NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair”, Blood Cancer Journal, 5, e311 (10 pages).
  32. Kaiyuan Yang, Zohre Hashemi, Wei Han, Alena Jin, Han Yang, Jocelyn Ozga, Liang Li and Catherine Chan, 2015, “Hydrolysis Enhances Bioavailability of Proanthocyanidin-Derived Metabolites and Improves b-Cell Function in Glucose Intolerant Rats”, Journal of Nutritional Biochemistry, 26, 850-859.
  33. Xiang Wang, Evan Berry, Samuel Hernandez-Anzaldo, Difei Sun, Ayinuer Adijiang, Liang Li, Dawei Zhang and Carlos Fernandez-Patron, 2015, “MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells”, FEBS Letters, 589, 490-496.
  34. Tao Huan and Liang Li, 2015, “Counting Missing Values in a Metabolite-Intensity Dataset for Measuring the Analytical Performance of a Metabolomics Platform”, Anal. Chem. 87, 1306-1313.
  35. Wei Xu, Deying Chen, Nan Wang, Ting Zhang, Ruokun Zhou, Tao Huan, Yingfeng Lu, Xiaoling Su, Qing Xie, Liang Li* and Lanjuan Li*, 2015, “Development of High-Performance Chemical Isotope Labeling LC-MS for Profiling the Human Fecal Metabolome”, Anal. Chem. 87, 829-836.  (Editors’ Highlight paper) (ACS Editors Choice paper)
  36. Ruokun Zhou and Liang Li, 2015, “Effects of Sample Injection Amount and Time-of-Flight Mass Spectrometric Detection Dynamic Range on Metabolome Analysis by High-Performance Chemical Isotope Labeling LC-MS”, Journal of Proteomics, 118, 130-139.

    2014


  37. Yiman Wu and Liang Li, 2014, “Dansylation Metabolite Assay: a Simple and Rapid Method for Sample Amount Normalization in Metabolomics”, Anal. Chem. 86, 9428-9433.
  38. Jun Peng, Kevin Guo, Jianguo Xia, Jianjun Zhou, Jing Yang, David Westaway, David S. Wishart and Liang Li, 2014, “Development of Isotope Labeling Liquid Chromatography Mass Spectrometry for Mouse Urine Metabolomics: Quantitative Metabolomic Study of Transgenic Mice Related to Alzheimer’s Disease”, J Proteome Res. 14, 4457-4469.
  39. Jun Peng, Yi-Ting Chen, Chien-Lun Chen and Liang Li, 2014, “Development of a Universal Metabolome-Standard Method for Long-term LC-MS Metabolome Profiling and Its Application for Bladder Cancer Urine-Metabolite-Biomarker Discovery”, Anal. Chem. 86, 6540-6547.
  40. Xiaoxia Ye and Liang Li, 2014, “Macro-porous Reversed Phase Separation of Proteins Combined with Reversed Phase Separation of Phosphopeptides and Tandem Mass Spectrometry for Profiling the Phosphoproteome of MDA-MB-231 cells”, Electrophoresis, 35, 3479-3486.
  41. Lu Chen, Nan Wang and Liang Li, 2014, “Development of microwave-assisted acid hydrolysis of proteins using a commercial microwave reactor and its combination with LC-MS for protein full-sequence analysis”, Talanta, 129, 290-295.
  42. Ruokun Zhou, Chiao-Li Tseng, Tao Huan and Liang Li, 2014, “IsoMS: Automated Processing of LC-MS Data Generated by a Chemical Isotope Labeling Metabolomics Platform”, Anal. Chem. 86, 4675-4679.
  43. Jun Peng, Chris D. St. Laurent, A. Dean Befus, Ruokun Zhou and Liang Li, 2014, “Metabolomic Profiling of Bronchoalveolar Lavage Fluids by Isotope Labeling Liquid Chromatography Mass Spectrometry: a Promising Approach to Studying Experimental Asthma”, Metabolomics, 10, 1305-1317.
  44. Yanan Tang, Ronghong Li, Guohui Lin and Liang Li, 2014, “PEP Search in MyCompoundID: Detection and Identification of Dipeptides and Tripeptides Using Dimethyl Labeling and Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry”, Anal. Chem. 86, 3568-3574.
  45. Chiao-Li Tseng and Liang Li, 2014, “High-Performance Isotope-Labeling Liquid Chromatography Mass Spectrometry for Investigating the Effect of Drinking Goji Tea on Urine Metabolome Profiling”, SCIENCE CHINA Chemistry (Special Issue on Mass Spectrometry Analysis), 57, 678-685.
  46. Nan Wang, Yanan Tang, Lu Chen and Liang Li, 2014, “Microbore Liquid Chromatography UV Detection for Quantification of Total Peptide Amount and Its Application for Assessing Sample Quality in Shotgun Proteome Analysis of Hundreds of Cells”, J Chromatogr. A, 1338, 51-57.
  47. R. Magnus N. Friis, John Paul Glaves, Tao Huan, Liang Li, Brian D. Sykes and Michael C. Schultz, 2014, “Rewiring AMPK and mitochondrial retrograde signaling for metabolic control of aging and histone acetylation in respiratory-defective cells”, Cell Reports, 7, 565-574.
  48. Lu Chen, Nan Wang, Difei Sun and Liang Li, 2014, “Microwave-Assisted Acid Hydrolysis of Proteins Combined with Peptide Fractionation and Mass Spectrometry Analysis for Characterizing Protein Terminal Sequences”, Journal of Proteomics, 100, 68-78.
  49. Ruokun Zhou and Liang Li, 2014, “Quantitative Metabolome Profiling Using Dansylation Isotope Labeling and LC-MS”, in Mass Spectrometry Methods in Metabolomics, Daniel Raftery, Ed.; Humana Press, New York; pp.127-136.
  50. Zhendong Li and Liang Li, 2014, “Chemical-vapor-assisted Electrospray Ionization for Increasing Analyte Signals in ESI Mass Spectrometry”, Anal. Chem. 86, 331-335.
  51. Difei Sun, Nan Wang and Liang Li, 2014, “In-gel Microwave-assisted Acid Hydrolysis of Proteins Combined with Liquid Chromatography Tandem Mass Spectrometry for Mapping Protein Sequences”, Anal. Chem. 86, 600-607.
  52. Xiaoxia Ye, Fang Wu, Peng Wang, Karen Jung, Yupo Ma, Liang Li and Raymond Lai, 2014, “b-Catenin, a Sox2 Binding Partner, Regulates the DNA Binding and Transcriptional Activity of Sox2 in Breast Cancer Cells”, Cellular Signalling, 26, 492-501.

    2013


  53. Ruokun Zhou, Kevin Guo and Liang Li, 2013, “5-Diethylamino-naphthalene-1-sulfonyl chloride (DensCl): a Novel Triplex Isotope Labeling Reagent for Quantitative Metabolome Analysis by Liquid Chromatography Mass Spectrometry”, Anal. Chem. 85, 11532-11539.

  54. Jun Peng and Liang Li, 2013, “Liquid-Liquid Extraction Combined with Differential Isotope Dimethylaminophenacyl Labeling for Improved Metabolomic Profiling of Organic Acids”, Anal. Chim. Acta. 803, 97-105.
  55. Feifei Fu, Victor W.T. Cheng, Yiman Wu, Yanan Tang, Joel H. Weiner and Liang Li, 2013, “Comparative Proteomic and Metabolomic Analysis of Staphylococcus warneri SG1 Cultured in the Presence and Absence of Butanol”, J. Proteome Res. 12, 4478-4489.
  56. Andy Lo, Joel H. Weiner and Liang Li, 2013, “Analytical Performance of Reciprocal Isotope Labeling of Proteome Digests for Quantitative Proteomics and Its Application for Comparative Studies of Aerobic and Anaerobic Escherichia coli Proteomes”, Anal. Chim. Acta. 795, 25-35.
  57. Yanan Tang and Liang Li, 2013, “Differential Isotope Dansylation Labeling Combined with Liquid Chromatography Mass Spectrometry for Quantification of Intact and N-terminal Truncated Proteins”, Anal. Chim. Acta. 792, 79-85.
  58. Andy Lo, Yanan Tang, Lu Chen and Liang Li, 2013, “Automation of Dimethylation-after-Guanidination (2MEGA) Labeling Chemistry and Its Compatibility to Common Buffers and Surfactants for Mass Spectrometry-Based Shotgun Quantitative Proteome Analysis”, Anal. Chim. Acta. 788, 81-88.
  59. Yanan Tang, John Mackey, Raymond Lai, Sunita Ghosh, Cheryl Santos, Kathryn Graham, Sambasivarao Damaraju, Manijeh Pasdar and Liang Li, 2013, “Quantitative Proteomic Analysis of HER2 Normal and Overexpressing MCF-7 Breast Cancer Cells Revealed Proteomic Changes Accompanied with HER2 Gene Amplification”, Journal of Proteomics, 91, 200-209.
  60. Yiman Wu and Liang Li, 2013, “Development of Isotope Labeling LC-MS for Metabolic Profiling of Bacterial Cells and Its Application for Bacterial Differentiation”, Anal. Chem. 85, 5755-5763. (Journal Cover Article)
  61. Mingguo Xu, Zhendong Li and Liang Li, 2013, “Combining Percolator with X!Tandem for Accurate and Sensitive Peptide Identification”, J. Proteome Res. 12, 3026-3033.
  62. Liang Li, 2013, “MALDI Mass Spectrometry for Polymer Characterization”, In “MALDI MS: A Practical Guide to Instrumentation, Methods and Applications, 2nd Edition”, Franz Hillenkamp and Jasna Peter-Katalinic, Eds., Wiley-VCH, Weinheim, Germany; pp313-354.
  63. Kermit K. Murray, Robert K. Boyd, Marcos N. Eberlin, G. John Langley, Liang Li and Yasuhide Naito, 2013, “Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013)”, Pure and Applied Chemistry, 85, 1515-1609.
  64. Liang Li, Ronghong Li, Jianjun Zhou, Azeret Zuniga, Avalyn E. Stanislaus, Yiman Wu, Tao Huan, Jiamin Zheng, Yi Shi, David S. Wishart, and Guohui Lin, 2013, “MyCompoundID: Using an Evidence-based Metabolome Library for Metabolite Identification”, Anal. Chem. 85, 3401-3408.
  65. Gengshu Wu, Liyan Zhang, Tete Li, Azeret Zuniga, Gary Lopaschuk, Liang Li, René L. Jacobs and Dennis E. Vance, 2013, “Choline Supplementation Promotes Hepatic Insulin Resistance in Phosphatidylethanolamine N-Methyltransferase-Deficient Mice via Increased Glucagon Action”, J. Bio. Chem., 288, 837-847.

    2012


  66. Jiamin Zheng, Roger A. Dixon and Liang Li, 2012, “Development of Isotope Labeling LC-MS for Human Salivary Metabolomics and Application to Profiling Metabolome Changes Associated with Mild Cognitive Impairment”, Anal. Chem. 84, 10802-10811.
  67. Yiman Wu and Liang Li, 2012, “Determination of Total Concentration of Chemically Labeled Metabolites as a Means of Metabolome Sample Normalization and Sample Loading Optimization in Mass Spectrometry-Based Metabolomics”, Anal. Chem. 84, 10723-10731.
  68. Avalyn Stanislaus, Kevin Guo, and Liang Li, 2012, “Development of an Isotope Labeling Ultra-High Performance Liquid Chromatography Mass Spectrometric Method for Quantification of Acylglycines in Human Urine”, Anal. Chim. Acta. 750, 161-72.
  69. Xiaoxia Ye and Liang Li, 2012, “Microwave-assisted Protein Solubilization for Mass Spectrometry-Based Shotgun Proteome Analysis”, Anal. Chem. 84, 6181-6191.
  70. Yi-Ting Chen, Fu-Shing Wang, Zhendong Li, Liang Li and Yong-Chien Ling, 2012, “Development of a Matrix-assisted Laser Desorption Ionization Mass Spectrometric Method for Rapid Process-monitoring of Phthalocyanine Compounds”, Anal. Chim. Acta. 736, 69-77.
  71. Nan Wang and Liang Li, 2012, “Microwave Digestion of Protein Samples for Proteomics Applications”, in Comprehensive Sampling and Sample Preparation, Volume 3; Janusz Pawliszyn, J.; Le, X.C; Li, X-F; Lee, H.K.; Eds.; Elsevier, Academic Press: Oxford, UK, pp 277-290.
  72. Jiamin Zheng and Liang Li, 2012, “Fragmentation of Protonated Dansyl-labeled Amines for Structural Analysis of Amine-containing Metabolites”, Int. J. Mass Spectrom., 316-318, 292-299.
  73. Difei Sun, Nan Wang, and Liang Li, 2012, “Integrated SDS Removal and Peptide Separation by Strong-Cation Exchange Liquid Chromatography for SDS-Assisted Shotgun Proteome Analysis”, J. Proteome Res. 11, 818-828.

    2011


  74. Mingguo Xu and Liang Li, 2011, “Validation of peptide MS/MS spectra using metabolic isotope labeling for spectral matching-based shotgun proteome analysis”, J. Proteome Res. 10, 3632-3641.
  75. Fang Wu, Difei Sun, Nan Wang, Yan Gong, Liang Li, 2011, “Comparison of surfactant-assisted shotgun methods using acid-labile surfactants and sodium dodecyl sulfate for membrane proteome analysis”, Anal. Chim. Acta. 698, 36-43.
  76. Leah C. Young, Kathleen M. Bone, Peng Wang, Fang Wu, Benjamin A Adam, Pascal Gelebart, Jelena Holovati, Liang Li, Susan E. Andrew and Raymond Lai, 2011, “Fusion tyrosine kinase NPM-ALK deregulates MSH2 and suppresses DNA mismatch repair function – novel insights into a potent oncoprotein”, The American Journal of Pathology, 179, 411-421.
  77. Kevin Guo, Jun Peng, Ruokun Zhou and Liang Li, 2011, “Ion-Pairing Reversed-Phase Liquid Chromatography Fractionation in Combination with Isotope Labeling Reversed-Phase Liquid Chromatography-Mass Spectrometry for Comprehensive Metabolome Profiling”, J. Chromatogr. A, 1218, 3689-3694.
  78. Azeret Zuniga and Liang Li, 2011, “Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry for Comprehensive Analysis of Urinary Acylcarnitines”, Anal. Chim. Acta. 689, 77-84.
  79. Kevin Guo, Fiona Bamforth and Liang Li, 2011, “Qualitative Metabolome Analysis of Human Cerebrospinal Fluid by 13C-/12C-Isotope Dansylation Labeling Combined with Liquid Chromatography Fourier Transform Ion Cyclotron Resonance Mass Spectrometry”, J. Am. Soc. Mass Spectrom. 22, 339-347.
  80. Peng Wang, Fang Wu, Jingdong Zhang, Todd McMullen, Leah C. Young, Robert J. Ingham, Liang Li, Raymond Lai, 2011, “Serine Phosphorylation of NPM-ALK, which is Dependent on the Auto-activation of the Kinase Activation Loop, Contributes to its Oncogenic Potential”, Carcinogenesis. 32, 146-153.
  81. Melisa Clements and Liang Li, 2011, “Strategy of Using Microsome-based Metabolite Production to Facilitate the Identification of Endogenous Human Metabolites by Liquid Chromatography Mass Spectrometry”, Anal. Chim. Acta. 685, 36-44.

    2010

  82. Avalyn E. Lewis-Stanislaus and Liang Li, 2010, “A Method for Comprehensive Analysis of Urinary Acylglycines by Using Ultra-Performance Liquid Chromatography Quadrupole Linear Ion Trap Mass Spectrometry”, J. Am. Soc. Mass Spectrom. 21, 2105-2116.
  83. Kevin Guo and Liang Li, 2010, “High Performance Isotope Labeling for Profiling Carboxylic Acid-Containing Metabolites in Biofluids by Mass Spectrometry”, Anal. Chem. 82, 8789-8793.
  84. Nan Wang and Liang Li, 2010, “Reproducible Microwave-assisted Acid Hydrolysis of Proteins Using a Household Microwave Oven and Its Combination with LC-ESI MS/MS for Mapping Protein Sequences and Modifications”, J. Am. Soc. Mass Spectrom. 21, 1573-1587.
  85. Bela Reiz and Liang Li, 2010, “Microwave-assisted Acid and Base Hydrolysis of Intact Proteins Containing Disulfide Bonds for Protein Sequence Analysis by Mass Spectrometry”, J. Am. Soc. Mass Spectrom. 21, 1596-1605.
  86. Fang Wu, Peng Wang, Jingdong Zhang, Leah C. Young, Raymond Lai and Liang Li, 2010, “Studies of Phosphoproteomic Changes Induced by NPM-ALK Highlight Deregulation of TNF/Fas/TRAIL Signaling Pathway in ALK-Positive Anaplastic Large Cell Lymphoma”, Molecular & Cellular Proteomics, 9, 1616-1632.
  87. Zackie Aktary, Kimberly Chapman, Le Lam, Andy Lo, Chengjie Ji, Kathryn Graham, Lillian Cook, Liang Li, John R. Mackey and Manijeh Pasdar, 2010, “Plakoglobin interacts with and increases the protein levels of metastasis suppressor Nm23-H2 and regulates the expression of Nm23-H1”, Oncogene, 29, 2118–2129.
  88. Nan Wang, Mingguo Xu, Peng Wang and Liang Li, 2010, “Development of Mass Spectrometry-Based Shotgun Method for Proteome Analysis of 500 to 5000 Cancer Cells”, Anal. Chem. 82, 2262-2271. (Highlighted in “Research Profile” written by R. Mukhopadhyay, “An MS method for proteomic analysis of small samples, Anal. Chem., 2010, 82, p 2598)
  89. Sambasivarao Damaraju, Nancy Zhang, Nan Li, Lidan Tao, Vijaya L. Damaraju, Jennifer Dufour, Cheryl Santos, Xue-Jun Sun, John Mackey, David S. Wishart, Carol E. Cass and Liang Li, 2010, “Evidence for Co-purification of Micronuclei in Sucrose Density Gradient Enriched Plasma Membranes from Cell Lines”, Anal. Biochem. 396, 69-75.
  90. Peng Wang, Fang Wu, Yupo Ma, Liang Li, Raymond Lai, and Leah C. Young, 2010, “Functional characterization of the kinase activation loop in nucleophosmin (NPM) -anaplastic lymphoma kinase (ALK) using tandem affinity purification and liquid chromatography-mass spectrometry”, J. Bio. Chem., 285, 95-103.

    2009

  91. Talat Yalcin and Liang Li, 2009, “Cobalt Coated Substrate for Matrix-free Analysis of Small Molecules by Laser Desorption Ionization Mass Spectrometry”, Appl. Surf. Sci. 256, 1309-1312.
  92. Liang Li, Ed., 2009, “MALDI Mass Spectrometry for Synthetic Polymer Analysis”, Wiley: New York, 299 pages. (also, “Overview of MS and MALDI MS for Polymer Analysis”, pp1-8)
  93. Liang Li and Randy M. Whittal, 2009, “Time-of-flight Mass Spectrometry for Polymer Characterization”, in MALDI Mass Spectrometry for Synthetic Polymer Analysis. Liang Li, Ed.; Wiley: New York, pp27-52.
  94. Andrea G. De Souza, Tyson J. MacCormack, Nan Wang, Liang Li and Greg G. Goss, 2009, “Large scale proteome profile of the zebrafish (Danio rerio) gill for physiological and biomarker discovery studies”, Zebrafish, 6, 229-238.
  95. Peng Wang, Andy Lo, J. Bryce Young, Jin Song, Raymond Lai, Norman Kneteman, Chunhai Hao and Liang Li, 2009, “Targeted Quantitative Mass Spectrometric Identification of Differentially Expressed Proteins between Bax-Expressing and Deficient Colorectal Carcinoma Cells”, J. Proteome Res. 8, 3403-3414.
  96. Kevin Guo and Liang Li, 2009, “Differential 12C-/13C-Isotope Dansylation Labeling and Fast Liquid Chromatography/Mass Spectrometry for Absolute and Relative Quantification of the Metabolome”, Anal. Chem. 81, 3919-3932.
  97. Fang Wu, Peng Wang, Leah C. Young, Raymond Lai and Liang Li, 2009, “Proteome-wide Identification of Novel Binding Partners to the Oncogenic Fusion Gene Protein, NPM-ALK, using Tandem Affinity Purification and MS”, The American Journal of Pathology, 174, 361-370.
  98. Nan Wang, Chuanhui Xie, J. Bryce Young and Liang Li, 2009, “Off-line Two-dimensional Liquid Chromatography with Maximized Sample Loading to Reversed-Phase LC-ESI Tandem Mass Spectrometry for Shotgun Proteome Analysis”, Anal. Chem. 81, 1049-1060.
  99. David S. Wishart, Craig Knox, An Chi Guo, Roman Eisner, Nelson Young, Bijaya Gautam, David D. Hau, Nick Psychogios, Edison Dong, Souhaila Bouatra, Rupasri Mandal, Igor Sinelnikov, Jianguo Xia, Leslie Jia, Joseph A. Cruz, Emilia Lim, Constance A. Sobsey, Savita Shrivastava, Paul Huang, Philip Liu, Lydia Fang, Jun Peng, Ryan Fradette, Dean Cheng, Dan Tzur, Melisa Clements, Avalyn Lewis, Andrea De Souza, Azaret Zuniga, Margot Dawe, Yeping Xiong, Derrick Clive, Russ Greiner, Alsu Nazyrova, Rustem Shaykhutdinov, Liang Li, Hans J. Vogel, and Ian Forsythe, 2009, “HMDB: a knowledge base for the human metabolome” Nucleic Acids Res. 37, D603 – D610.
  100. Nan Wang, J. Bryce Young and Liang Li, 2009, “Liquid Chromatography MALDI MS/MS for Membrane Proteome Analysis”, In Methods in Molecular Biology, vol. 528: Methods in the Proteomics of Membrane Proteins. Robin Wait and Matthew Peirce, Eds., Humana Press Inc., Totowa, NJ. pp.295-310.

    2008

  101. Nan Zhang, Andrew R. E. Shaw, Nan Li, Rui Chen, Allan Mak, Nelson Young, David Wishart and Liang Li, 2008, “Liquid Chromatography Electrospray Ionization and Matrix-Assisted Laser Desorption Ionization Tandem Mass Spectrometry for the Analysis of Lipid Raft Proteome of Monocytes”, Anal. Chim. Acta. 627, 82-90.
  102. Joel H. Weiner and Liang Li, 2008, “Proteome of the Escherichia coli Envelope and Technological Challenges in Membrane Proteome Analysis”, Biochimica et Biophysica Acta (BBA) – Biomembranes 1778, 1698-1713.
  103. David S. Wishart, Michael J. Lewis, Joshua A. Morrissey, Mitchel D. Flegel, Kevin Jeroncic, Yeping Xiong, Dean Cheng, Roman Eisner, Bijaya Gautam, Dan Tzur, Summit Sawhney, Fiona Bamforth, Russ Greiner, Liang Li, 2008, “The Human Cerebrospinal Fluid Metabolome”, Journal of Chromatography B. (special issue on metabolomics), 871, 164-173.
  104. Yan Gong, Nan Wang, Fang Wu, Carol E. Cass, Sambasivarao Damaraju, John R. Mackey and Liang Li, 2008, “Proteome Profile of Human Breast Cancer Tissue Generated by LC-ESI MS/MS Combined with Sequential Protein Precipitation and Solubilization”, J. Proteome Res. 7, 3583-3590.
  105. Nan Wang and Liang Li, 2008, “Exploring the Precursor Ion Exclusion Feature of LC-ESI Quadrupole Time-of-Flight MS for Improving Protein Identification in Shotgun Proteome Analysis”, Anal. Chem. 80, 4696-4710.
  106. Kevin Guo, Chengjie Ji and Liang Li, 2007, “Stable-Isotope Dimethylation Labeling Combined with LC-ESI MS for Quantification of Amine-containing Metabolites in Biological Samples”, Anal. Chem. 79, 8631-8638.

    2007

  107. J. Bryce Young and Liang Li, 2007, “Impulse-Driven Heated-Droplet Deposition Interface for Capillary and Microbore LC-MALDI MS and MS/MS”, Anal. Chem. 79, 5927-5934.
  108. Mahmoud M. Yassine, Nan Guo, Hongying Zhong, Liang Li and Charles A. Lucy, 2007, “Off-line Coupling of Preparative Capillary Zone Electrophoresis with Microwave-assisted Acid Hydrolysis and Matrix-assisted Laser Desorption Ionization Mass Spectrometry for Protein Sequencing”, Anal. Chim. Acta. 597, 41-49.
  109. Chengjie Ji, Nan Zhang, Sambasivarao Damaraju, Vijaya L. Damaraju, Pat Carpenter, Carol E. Cass and Liang Li, 2007, “A Study of Reproducibility of Guanidination-Dimethylation Labeling and Liquid Chromatography Matrix-Assisted Laser Desorption Ionization Mass Spectrometry for Relative Proteome Quantification”, Anal. Chim. Acta. 585, 219-226.
  110. Mackenzie E. Malo, Liang Li and Larry Fliegel, 2007, “Mitogen-activated protein kinase-dependent activation of the Na+/H+ exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771”, J. Bio. Chem., 282, 6292-6299.
  111. Nan Zhang, Rui Chen, Nelson Young, David Wishart, Philip Winter, Joel H. Weiner and Liang Li, 2007, “Comparison of SDS- and Methanol-Assisted Protein Solubilization and Digestion Methods for Escherichia coli Membrane Proteome Analysis by 2D-LC-MS/MS”, Proteomics, 7, 484-493.
  112. Mulu Gebremedhin, Hongying Zhong, Shaohua Wang, Michael Weinfeld and Liang Li, 2007, “Benefit of Microwave-Assisted Acid Hydrolysis of Proteins for Mass Spectrometric Profiling of the Human Heart Tissue Proteome”, Rapid Commun. Mass Spectrom. 21, 2779-2783.
  113. David S. Wishart, Dan Tzur, Craig Knox, Roman Eisner, An Chi Guo, Nelson Young, Dean Cheng, Kevin Jewell, David Arndt, Summit Sawhney, Chris Fung, Lisa Nikolai, Mike Lewis, Marie-Aude Coutouly, Ian Forsythe, Peter Tang, Savita Shrivastava, Kevin Jeroncic, Paul Stothard, Godwin Amegbey, David Block, David. D. Hau, James Wagner, Jessica Miniaci, Melisa Clements, Mulu Gebremedhin, Natalie Guo, Ying Zhang, Gavin E. Duggan, Glen D. MacInnis, Alim M. Weljie, Reza Dowlatabadi, Fiona Bamforth, Derrick Clive, Russ Greiner, Liang Li, Tom Marrie, Brian D. Sykes, Hans J. Vogel and Lori Querengesser, 2007, “HMDB: The Human Metabolome Database”, Nucleic Acids Res., 35, D521-D526.
  114. Nan Wang, Lauren MacKenzie, Andrea G. De Souza, Hongying Zhong, Greg Goss and Liang Li, 2007, “Proteome Profile of Cytosolic Component of Zebrafish Liver Generated by LC-ESI MS/MS Combined with Trypsin Digestion and Microwave-Assisted Acid Hydrolysis “, J. Proteome Res., 6, 263-272.
  115. Liang Li, 2007, “MALDI Mass Spectrometry for Polymer Characterization”, In “MALDI MS: A Practical Guide to Instrumentation, Methods and Applications”, Franz Hillenkamp and Jasna Peter-Katalinic, Eds., Wiley-VCH, Germany 2007, 245-297.

    2006

  116. Chengjie Ji, Andy Lo, Sandra Marcus and Liang Li, 2006, “Effect of 2MEGA Labeling for Membrane Proteome Analysis Using LC-ESI QTOF MS”, J. Proteome Res., 5, 2567-2576.
  117. Chengjie Ji, Zhengping Wang and Liang Li, 2006, “Protein Mass Measurement Combined with Mass Spectrometric Sequencing of Protein Digests for Detection and Characterization of Protein Modifications”, Canadian Journal of Chemistry, 84, 986-997.
  118. Bernd O. Keller and Liang Li, 2006, “Three-Layer Matrix/Sample Preparation Method for MALDI MS Analysis of Low Nanomolar Protein Samples”, J. Am. Soc. Mass Spectrom. 17, 780-785.
  119. J. Bryce Young and Liang Li, 2006, “Coupling of LC and MALDI-MS: techniques, instrumentation and application”, In “Encyclopedia of Mass Spectrometry: Hyphenated Methods”, W. M. A. Niessen, Ed., Elsevier, Amsterdam, 2006, Vol. 8. 273-283.
  120. J. Bryce Young and Liang Li, 2006, “An Impulse-Driven Liquid-Droplet Deposition Interface for Combining LC with MALDI MS and MS/MS”, J. Am. Soc. Mass Spectrom. 17, 325-334.
  121. Jacek P. Dworzanski, Samir V. Deshpande, Rui Chen, Rabih E. Jabbour, A. Peter Snyder, Charles H. Wick and Liang Li, 2006, “Mass Spectrometry-Based Proteomics Combined with Bioinformatic Tools for Bacterial Classification”, J. Proteome Res. 5, 76-87.

    2005

  122. Chengjie Ji, Nan Guo and Liang Li, 2005, “Differential Dimethyl Labeling of N-termini of Peptides after Guanidination for Proteome Analysis”, J. Proteome Res. 4, 2099-2108.
  123. Nan Li, Nan Wang, Jing Zheng, X. Michael Liu, O. William Lever, Paul M. Erickson, and Liang Li, 2005, “Characterization of Human Tear Proteome Using Multiple Proteomic Analysis Techniques”, J. Proteome Res. 4, 2052-2061.
  124. Jing Zheng, Nan Li, Marc Ridyard, Hui Dai, Stephen M. Robbins, and Liang Li, 2005, “Simple and Robust Two-Layer Matrix/Sample Preparation Method for MALDI MS/MS Analysis of Peptides”, J. Proteome Res. 4, 1709 -1716.
  125. Sharon Barker, Michael Weinfeld, Jing Zheng, Liang Li, and David Murray, 2005, “The identification of mammalian proteins crosslinked to DNA by ionizing radiation “, J. Biol. Chem., 280, 33826-33838.
  126. Sharon Barker, David Murray, Jing Zheng, Liang Li, and Michael Weinfeld, 2005, “A Method for the Isolation of Covalent DNA-Protein Crosslinks Suitable for Proteomics Analysis”, Anal. Biochem. 334, 204-215.
  127. Chengjie Ji, Laiji Li, Mulu Gebre, Manijeh Pasdar and Liang Li, 2005, ” Identification and Quantification of Differentially Expressed Proteins in E-Cadherin Deficient SCC9 Cells and SCC9 Transfectants Expressing E-Cadherin by Dimethyl Isotope Labeling, LC-MALDI MS and MS/MS”, J. Proteome Res. 4, 1419-1426.
  128. Chengjie Ji and Liang Li, 2005, “Quantitative Proteome Analysis Using Differential Stable Isotopic Labeling and Microbore LC-MALDI MS and MS/MS”, J. Proteome Res. 4, 734-742.
  129. Hongying Zhong and Liang Li, 2005, “An Algorithm for Interpretation of Low Energy Collision-Induced Dissociation Product Ion Spectra for de novo Sequencing of Peptides”, Rapid Commun. Mass Spectrom. 19, 1084-1096.
  130. David Craft and Liang Li, 2005, “An Integrated Sample Processing System Involving On-Column Protein Adsorption, Sample Washing, and Enzyme Digestion for Protein Identification by LC-ESI MS/MS”, Anal. Chem. 77, 2649-2655.
  131. Jacek Stupak, Huaizhi Liu, Zhengping Wang, Brenda J. Brix, Larry Fliegel, and Liang Li, 2005, “Nanoliter Sample Handling Combined with Microspot MALDI-MS for Detection of Gel-Separated Phosphoproteins”, J. Proteome Res. 4, 515-522.
  132. Hongying Zhong, Sandra Marcus and Liang Li, 2005, “Microwave-Assisted Acid Hydrolysis of Proteins Combined with LC MALDI MS/MS for Protein Identification”, J. Am. Soc. Mass Spectrom. 16, 471-481.
  133. Yong Zheng, Huaizhi Liu, Jason Coughlin, Jing Zheng, Liang Li, James C. Stone, 2005, “Phosphorylation of RASGRP3 on Threonine 133 Provides a Mechanistic Link between PKC and RAS Signaling Systems in B Cells”, Blood, 105, 3648-3654.
  134. Chang Xiao, Bao Feng Yang, Jin H. Song, Howard Schulman, Liang Li and Chunhai Hao, 2005 “Inhibition of CaMKII-mediated c-FLIP Expression Sensitizes Malignant Melanoma Cells to TRAIL-Induced Apoptosis”, Experimental Cell Research, 304, 244-255.
  135. Chris McDonald and Liang Li, 2005, “Limited Proteolysis Combined with Isotope Labeling and Quantitative LC-MALDI MS for Monitoring Protein Conformational Changes: A Study on Calcium-Binding Sites of Cardiac Troponin C”, Analytica Chimica Acta (special issue on protein interactions), 534, 3-10.

    2004

  136. Hongying Zhong, Ying Zhang, Zhihui Wen and Liang Li, 2004, “Protein Sequencing by Mass Analysis of Polypeptide-Ladders after Controlled Protein Hydrolysis”, Nature Biotechnology, 22, 1291-1296.
  137. Hongying Zhong, Sandra Marcus and Liang Li, 2004, “Two-dimensional Mass Spectra Generated from the Analysis of 15N-Labeled and Unlabeled Peptides for Efficient Protein Identification and de novo Peptide Sequencing”, J. Proteome Res., 3, 1155-1163.
  138. Lidan Tao, Xinlei Yu, A. Peter Snyder, and Liang Li, 2004, “Bacterial Identification by Protein Mass Mapping Combined with an Experimentally-Derived Protein Mass Database”, Anal. Chem., 76, 6609-6617.
  139. Nan Li, Andrew R. E. Shaw, Nan Zhang, Allan Mak, and Liang Li, 2004, “Lipid Raft Proteomics: Analysis of In-Solution Digest of SDS-Solubilized Lipid Raft Proteins by LC-MALDI Tandem Mass Spectrometry”, Proteomics, 4, 3156-3266.
  140. Huaizhi Liu, Jacek Stupak, Jing Zheng, Bernd Keller, Brenda J. Brix, Larry Fliegel, and Liang Li, 2004, “Open Tubular Immobilized Metal–Ion Affinity Chromatography Combined with MALDI MS and MS/MS for Identification of Protein Phosphorylation Sites”, Anal. Chem. 76, 4223-4232.
  141. Jacek P. Dworzanski, A. Peter Snyder, Rui Chen, Haiyan Zhang, David Wishart, Liang Li, 2004, “A Proteomic Approach for Identification of Bacteria Using Tandem Mass Spectrometry Combined with a Translatome Database and Statistical Scoring”, Anal. Chem. 76, 2355-2366.
  142. Nan Zhang and Liang Li, 2004, “Effects of Common Surfactants on Protein Digestion and MALDI MS Analysis of the Digested Peptides Using Two-Layer Sample Preparation”, Rapid Commun. Mass Spectrom. 18, 889-896.
  143. Boyan Zhang, Chris McDonald, and Liang Li, 2004, “Combining Liquid Chromatography with MALDI Mass Spectrometry Using a Heated Droplet Interface”, Anal. Chem. 76, 992-1001.
  144. Nan Zhang, Nan Li, and Liang Li, 2004, “Liquid Chromatography MALDI MS/MS for Membrane Proteome Analysis”, J. Proteome Res. 3, 719-727.
  145. Ghahary A, Krimi-Busheri F, Marcoux Y, Li Y, Tredget EE, Kilani RT, Li L, Zheng J, Karami A, Keller B, Weinfeld M, 2004 “Keratinocyte Releasable Stratifin Functions as a Potent Collagenase Stimulating Factor in Fibroblasts”, J. Investigative Dermatology, 122(5), 1188-1197.

    2003

  146. Andrew R. Shaw and Liang Li, 2003, “Exploration of the Functional Proteome: Lessons from Lipid Rafts”, Current Opinion in Molecular Therapeutics, 5, 294-301.
  147. G. Tarikere, W.Q. Li, S. Catalano, J. Bogenberger, J. Zheng, B. Keller, J. Vialard, M. Janicot, L. Li, Y. Hitoshi, D.G. Payan, D.C. Anderson, 2003, “Cellular Interacting Proteins of Functional Screen-Derived Antiproliferative and Cytotoxic Peptides Discovered Using Shotgun Peptide Sequencing”, Chemistry & Biology, 10, 927-937.
  148. B. Knoblach, B.O. Keller, J. Groenendyk, S. Aldred, J. Zheng, B.D. Lemire, L. Li, M. Michalak, 2003, “ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins”, Molecular and Cellular Proteomics, 2, 1104-1119.
  149. Thuy Tien T. Quach, Nan Li, Dawn P. Richards, Jing Zheng, Bernd O. Keller and Liang Li, 2003, “Development and Applications of In-gel CNBR/Tryptic Digestion Combined with Mass Spectrometry for the Analysis of Membrane Proteins”, J. Proteome Res., 2, 543-552.
  150. Alan Doucette, David Craft and Liang Li, 2003, “Mass Spectrometric Study of the Effects of Hydrophobic Surface Chemistry and Morphology on the Digestion of Surface-Bound Proteins”, J. Am. Soc. Mass Spectrom., 14, 203-214.
  151. Nan Li, Allan Mak, Dawn P. Richards, Claudia Naber, Bernd O. Keller, Liang Li and Andrew R. Shaw, 2003, “Monocyte Lipid Rafts Contain Proteins Implicated in Vesicular Trafficking and Phagosome Formation”, Proteomics, 3, 536-548.

    2002

  152. David Craft, Alan Doucette and Liang Li, 2002, “Microcolumn Capture and Digestion of Proteins Combined with Mass Spectrometry for Protein Identification”, Journal of Proteome Research, 1, 537-547.
  153. Wojciech Gabryelski and Liang Li, 2002, “Photo-induced dissociation of electrospray generated ions in an ion trap/time-of-flight mass spectrometer using a pulsed CO2 laser”, Rapid Commun. Mass Spectrom., 16, 1805-1811.
  154. Talat Yalcin, William E. Wallace, Charles M. Guttman, and Liang Li, 2002, “Metal Powder Substrate-Assisted Laser Desorption Ionization Mass Spectrometry for Polyethylene Analysis”, Anal. Chem., 74, 4750-4756.
  155. Zhengping Wang, Kevin Dunlop, S. Randolph Long, Liang Li, 2002, “Mass Spectrometric Methods for Generation of Protein Mass Database Used for Bacterial Identification”, Anal. Chem., 74, 3174-3182.
  156. Bernd O. Keller, Zhengping Wang, and Liang Li, 2002, “Low-Mass Proteome Analysis Based on HPLC Fractionation, Nanoliter Protein Concentration/Digestion, and Microspot MALDI MS”, Journal of Chromatography B, Special Issue on Proteomics and Genomics, 782, 317-329.
  157. F. Karimi-Busheri, Y. Marcoux, E. E. Tredget, L. Li, J. Zheng, M. Ghoreishi, M. Weinfeld, and A. Ghahary, 2002, “Expression of a Releasable Form of Annexin II by Human Keratinocytes”, Journal of Cellular Biochemistry, 86, 737-747.
  158. Rui Chen, Xinlei Yu, and Liang Li, 2002, “Characterization of Poly(Ethylene Glycol) Esters Using Low Energy Collision-Induced Dissociation in Electrospray Ionization Mass Spectrometry”, J. Am. Soc. Mass Spectrom., 13, 888-897.
  159. Nan Zhang and Liang Li, 2002, “Ammonium Dodecyl Sulfate as an Alternative to Sodium Dodecyl Sulfate for Protein Sample Preparation with Improved Performance in MALDI Mass Spectrometry”, Anal. Chem., 74,1729-1736.

    2001

  160. Ken K.C. Yeung, Andrea G. Kiceniuk, and Liang Li, 2001, “Capillary Electrophoresis Using a Surfactant-treated Capillary Coupled with Offline Matrix-Assisted Laser Desorption Mass Spectrometry for High Efficiency and Sensitivity Detection of Proteins”, J. Chromatography A, 931, 153-162.
  161. Rui Chen, Talat Yalcin, William E. Wallace, Charles M. Guttman, and Liang Li, 2001, “Laser Desorption Ionization and MALDI Time-of-Flight Mass Spectrometry for Low Molecular Mass Polyethylene Analysis”, J. Am. Soc. Mass Spectrom., 12, 1186-1192.
  162. Kevin Y. Dunlop and Liang Li, 2001, “Automated mass analysis of low-molecular-mass bacterial proteome by liquid chromatography-electrospray ionization mass spectrometry”, J. Chromatography A, 925, 123-132.
  163. Bernd O. Keller and Liang Li, 2001, “Detection of 25,000 Molecules of Substance P by MALDI-TOF Mass Spectrometry and Investigations into the Fundamental Limits of Detection in MALDI”, J. Am. Soc. Mass Spectrom., 12, 1055-1063.
  164. Bernd O. Keller and Liang Li, 2001, “Nanoliter Solvent Extraction Combined with Microspot MALDI TOF Mass Spectrometry for the Analysis of Hydrophobic Biomolecules”, Anal. Chem., 73, 2929-2936.
  165. Nan Zhang, Alan Doucette and Liang Li, 2001, “Two-Layer Sample Preparation Method for MALDI Mass Spectrometric Analysis of Protein and peptide Samples Containing Sodium Dodecyl Sulfate”, Anal. Chem., 73, 2968-2975.
  166. Alan Doucette and Liang Li, 2001, “Investigation of the Applicability of a Sequential Digestion Protocol Using Trypsin and Leucine Aminopeptidase M for Protein Identification by MALDI-TOF Mass Spectrometry”, joint-issues of Proteomics 1, 987-1000, and European Journal of Mass Spectrometry, 7, 157-170.
  167. Tony K.-K. Mong, Aizhen Niu, Hak-Fun Chow, Chi Wu, Liang Li, and Rui Chen, 2001 “beta-alanine-based dendritic beta-peptides: Dendrimers possessing unusually strong binding ability towards protic solvents and their self-assembly into nanoscale aggregates through hydrogen-bond interactions”, Chem. Eur. J., 7, 686-699.
  168. Rui Chen, Amy M. Tseng, Mary Uhing, L. Li, 2001, “Application of an Integrated Matrix-Assisted Laser Desorption/Ionization Time-of-Flight, Electrospray Ionization Mass Spectrometry and Tandem Mass Spectrometry Approach to Characterizing Complex Polyol Mixtures”, J. Am. Soc. Mass Spectrom., 12, 55-60.
  169. Kalal Derhami, Jing Zheng, Liang Li, Johan F. Wolfaardt, and Paul G. Scott, 2001, “Proteomic Analysis of Human Skin Fibroblasts Grown on Titanium: a Novel Approach to Study Molecular Biocompatibility”, Journal of Biomedical Materials Research, 56, 234-244.
  170. R. Chen, L. Li, 2001, “Reactions of Atomic Transition-Metal Ions with Long-Chain Alkanes”, J. Am. Soc. Mass Spectrom. 12, 367-375.
  171. Rui Chen and Liang Li, 2001, “Lithium and Transition Metal Ions Enable Low Energy Collision-Induced Dissociation of Polyglycols in Electrospray Ionization Mass Spectrometry”, J. Am. Soc. Mass Spectrom., 12, 832-839.

    2000

  172. B.O. Keller, L. Li, 2000, “Discerning Matrix-Cluster Peaks in MALDI-TOF Mass Spectra of Dilute Peptide Mixtures”, J. Am. Soc. Mass Spectrom., 11, 88-93.
  173. A. Doucette, D. Craft, L. Li, 2000, “Protein Concentration and Enzyme Digestion on Microbeads for MALDI-TOF Peptide Mass Mapping of Proteins from Dilute Solutions”, Anal. Chem. 72, 3355-3362.
  174. T. Yalcin, W. Gabryelski, L. Li, 2000, “Structural Analysis of Polymer End Groups by Electrospray Ionization High-Energy Collision-Induced Dissociation Tandem Mass Spectrometry”, Anal. Chem., 72, 3847-3852.
  175. K.G. Lichtenwalter, A. Apffel, J. Bai, J.A. Chakel, Y.Q. Dai, K.M. Hahnenberger, L. Li, W.S. Hancock, 2000, “Approaches to Functional Genomics: Potential of MALDI-TOF Mass Spectrometry Combined with Separation Methods for the Analysis of DNA in Biological Samples”, J. Chromatogr. B, 745, 231-241.
  176. L. Li, 2000, “Mass Spectrometry for Polymer Characterization”, Polymer Prepr. 41, 627-628
  177. Rui Chen, Nan Zhang, Amy M. Tseng, Liang Li, 2000, “Effects of MALDI Experimental Conditions on Quantitative Composition Analysis of Ethylene Oxide/Propylene Oxide Copolymer”, Rapid Commun. Mass Spectrom., 14, 1-7.

    1999

  178. W. Gabryelski, L. Li, 1999, “Photo-induced Dissociation of Electrospray Generated Ions in an Ion-Trap/Time-of-Flight Mass Spectrometer”, Rev. Sci. Instrum., 70, 4192-4199.
  179. M.A. Jeannot, J. Zheng, L. Li, 1999, “Observation of SDS-PAGE Gel-Induced Protein Modifications and Its Implications for Accurate Molecular Weight Determination of Gel-Separated Proteins by MALDI TOFMS”, J. Am. Soc. Mass Spectrom., 10, 512-520.
  180. Y.Q. Dai, R.M. Whittal, L. Li, 1999, “Two-Layer Sample Preparation: an Effective Method for MALDI-MS Analysis of Complex Peptide and Protein Mixtures”, Anal. Chem., 71, 1087-1091.
  181. Y.Q. Dai, L. Li, D.C. Roser, S.R. Long, 1999, “Detection and Identification of Low-Mass Peptides and Proteins from Solvent Suspensions of Escherichia coli by HPLC Fractionation and MALDI Mass Spectrometry”, Rapid Communications in Mass Spectrometry, 13, 73-78.

    1998

  182. R.M. Whittal, B.O. Keller, L. Li, 1998, “Nanoliter Chemistry Combined with Mass Spectrometry for Peptide Mapping of Proteins from Single Mammalian Cell Lysates”, Anal. Chem., 70, 5344-5347.
  183. T. Yalcin, Y.Q. Dai, L. Li, 1998, “MALDI-TOF Mass Spectrometry for Polymer Analysis: Solvent Effect in Sample Preparation”, J. Am. Soc. Mass Spectrom., 9, 1303-1310.
  184. D.C. Schriemer, D.R. Bundle, L. Li, O. Hindsgaul, 1998, “Micro-scale Frontal Affinity Chromatography with Mass Spectrometric Detection: A New Method for the Screening of Compound Libraries”, Angewandte Chemie Int. Ed. 37, 3383-3387.
  185. T. Yalcin, W. Gabryelski, L. Li, 1998, “Dissociation of Protonated Phenylthiohydantoin-Amino Acids and Phenylthiocarbamoyl-Dipeptides”, J. Mass Spectrom., 33, 543-553.
  186. W. Gabryelski, R.W. Purves, L. Li, 1998, “Characterization of an Electrospray Ionization Ion Trap/Linear Time-of-Flight Mass Spectrometer for Phenylthiohydantoin (PTH)-Amino Acid Analysis”, Int. J. Mass Spectrom. Ion Processes, 176, 213-225.
  187. R.W. Purves, W. Gabryelski, L. Li, 1998, “Investigation of the Quantitative Capabilities of an Electrospray Ionization Ion-Trap/Linear Time-of-Flight Mass Spectrometer”, Rapid Communications in Mass Spectrometry, 12, 695-700.
  188. Z.P. Wang, L.M. Russon, L. Li, D.C. Roser, S.R. Long, 1998, “Investigation of Spectral Reproducibility in Direct Analysis of Bacteria Proteins by MALDI-TOFMS”, Rapid Communications in Mass Spectrometry, 12, 456-464.
  189. D.C. Schriemer, T. Yalcin, L. Li, 1998, “MALDI Mass Spectrometry Combined with Avidin-Biotin Chemistry for Analysis of Protein Modifications”, Anal. Chem., 70, 1569-1575.
  190. H.H. Zhu, T. Yalcin, L. Li, 1998, “Analysis of the Accuracy of Determining Average Molecular Weights of Narrow Polydisperse Polymers by MALDI Time-of-Flight Mass Spectrometry”, J. Am. Soc. Mass Spectrom., 9, 275-281.
  191. S.B. Chun, C.D. Han, S.F. Hahn, S.Q. Harper, P.J. Savickas, D.M. Meunier, L. Li, T. Yalcin, 1998, “Phase Behavior of Polystyrene/Polybutadiene and Polystyrene/Hydrogenated Polybutadiene Mixtures: Effect of the Microstructure of Polybutadiene”, Macromolecules, 31, 394-402.
  192. R.M. Whittal, L.M. Russon, L. Li, 1998, “Development of LC-MS Using Continuous-Flow MALDI Time-of-Flight Mass Spectrometry”, J. Chromatogr. A., 794, 367-375.

    1997

  193. T. Yalcin, D.C. Schriemer, L. Li, 1997, “MALDI Time-of-Flight Mass Spectrometry for the Analysis of Polydienes”, J. Am. Soc. Mass Spectrom., 8, 1220-1229.
  194. D.C. Schriemer, L. Li, 1997, “Mass Discrimination in the Analysis of Polydisperse Polymers by MALDI Time-of-Flight Mass Spectrometry. 1. Sample Preparation and Desorption/Ionization Issues”, Anal. Chem., 69, 4169-4175.
  195. D.C. Schriemer, L. Li, 1997, “Mass Discrimination in the Analysis of Polydisperse Polymers by MALDI Time-of-Flight Mass Spectrometry. 2. Instrumental Issues”, Anal. Chem., 69, 4176-4183.
  196. R.M. Whittal, L. Li, 1997, “Time-Lag Focusing Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry”, American Laboratory, 24, 30-36.
  197. R.W. Purves, W. Gabryelski, L. Li, 1997, “The Effect of Using Silicon Based Diffusion Pump Fluid on Spectral Quality in an Electrospray Ionization Ion Trap/Time-of-Flight Mass Spectrometer”, Rev. Sci. Instrum., 68, 3252-3253.
  198. Y.Q. Dai, R.M. Whittal, C.A. Bridges, Y. Isogai, O. Hindsgaul, L. Li, 1997, “Matrix-Assisted Laser Desorption Ionization Mass Spectrometry for the Analysis of Monosulfated Oligosaccharides”, Carbohydrate Research., 304, 1-9.
  199. R.W. Purves, L. Li, 1997, “Development and Characterization of an Electrospray Ionization Ion Trap/Linear Time-of-Flight Mass Spectrometer”, J. Am. Soc. Mass Spectrom., 8, 1085-1093.
  200. R.M. Whittal, D.C. Schriemer, L. Li, 1997, “Time-Lag Focusing MALDI Time-of-Flight Mass Spectrometry for Industrial Polymer Characterization: Oligomer Resolution, Mass Accuracy, and Average Weight Information”, Anal. Chem., 69, 2734-2741.
  201. R.M. Whittal, L.M. Russon, S.R. Weinberger, L. Li, 1997, “Functional Wave Time-Lag Focusing MALDI in a Linear Time-of-Flight Mass Spectrometer: Improved Mass Accuracy”, Anal. Chem., 69, 2147-2153.
  202. D.M. Schriemer, R.M. Whittal, L. Li, 1997, “Analysis of Structurally Complex Polymers by Time-Lag Focusing Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry”, Macromolecules, 30, 1955-1963.

    1996

  203. L. Li, R.E. Golding, R.M. Whittal, 1996, “Analysis of Single Mammalian Cell Lysates by Mass Spectrometry”, J. Am. Chem. Soc., 118, 11662-11663.
  204. D.M. Schriemer, Y.Q. Dai, L. Li, 1996, “Effect of Sample Compositions on Chemical Analysis Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry”, Proc. SPIE-Int. Soc. Opt. Eng., 2835, 95-106.
  205. Y.Q. Dai, R.M. Whittal, L. Li, S.R. Weinberger, 1996, “Accurate Mass Measurement of Oligo­nucleo­tides using a Time-Lag Focusing MALDI Time-of-Flight Mass Spectrometer”, Rapid Communications in Mass Spectrometry, 10, 1792-1796.
  206. D.C. Schriemer, L. Li, 1996, “Combining Avidin-Biotin Chemistry with Matrix-Assisted Laser Desorption Ionization Mass Spectrometry”, Anal. Chem., 68, 3382‑3387.
  207. Y.Q. Dai, R.M. Whittal, L. Li, 1996, “Confocal Fluorescence Microscopic Imaging for Investigating the Analyte Distribution in MALDI Matrices”, Anal. Chem., 68, 2494‑2500.
  208. D.C. Schriemer, L. Li, 1996, “Detection of High Molecular Weight Narrow Polydisperse Polymers up to 1.5 Million Daltons by MALDI Mass Spectrometry”, Anal. Chem., 68, 2721‑2725. (Accelerated Article)
  209. S. Lee, M.A. Winnik, R.M. Whittal, L. Li, 1996, “Synthesis of Symmetric Fluorescently Labeled Polyethylene Glycols Using Phosphoramidites of Pyrenebutanol and Their Characterization by MALDI Mass Spectrometry”, Macromolecules , 29, 3060‑3072.
  210. D.C. Schriemer, L. Li, 1996, “Surface Analysis of Bulk Polymers Using Laser-Induced Photoelectron Ionization with Laser Desorption in a Time-of-Flight Mass Spectrometer”, Anal. Chem., 18, 250‑256.
  211. R.M. Whittal, L. Li, S. Lee, M. A. Winnik, 1996, “Characterization of Pyrene End-Labeled Polyethylene Glycol by High Resolution MALDI Time-of-Flight Mass Spectrometry, Macromol. Rapid Commun., 17, 59‑64.

    1995

  212. R.W. Purves, L. Li, 1995, “Development of an Ion Trap/Linear Time-of-Flight Mass Spectrometer with Electrospray Ionization for Microcolumn Liquid Chromatography Detection”, J. Microcolumn Separation , 7, 603‑610.
  213. R.M. Whittal, M.M. Palcic, O. Hindsgaul, L. Li, 1995, “Direct Analysis of Enzymatic Reactions of Oligo­saccharides in Human Serum Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry”, Anal. Chem., 67, 3509-3514.
  214. D.S. Nagra, L. Li, 1995, “Liquid Chromatography/Time-of-Flight Mass Spectrometry with Continuous-Flow Matrix-Assisted Laser Desorption Ionization”, J. Chromatogr. A, 711, 235‑245.
  215. R.M. Whittal, L. Li, 1995, “High Resolution Matrix-Assisted Laser Desorption Ionization in a Linear Time-of-Flight Mass Spectrometer”, Anal. Chem., 67, 1950-1954. (Accelerated Article)
  216. D.C. Schriemer, L. Li, 1995, “A Dual Ionization Source with Laser Desorption Sample Introduction in a Time-of-Flight Mass Spectrometer”, Instrum. Science & Technology, 23, 4-10.
  217. D.C. Schriemer, L. Li, 1995, “Laser-Induced Surface Ionization in a Time-of-Flight Mass Spectrometer”, Rev. Sci. Instrum., 66, 55‑62.

    1994

  218. A.P.L. Wang, X.J. Guo, L. Li, 1994, “Liquid Chromatography/Time-of-Flight Mass Spectro­metry with a Pulsed Sample Introduction Interface”, Anal. Chem., 66, 3664‑3675.
  219. L.D. Coulson, D.S. Nagra, X.J. Guo, R.M. Whittal, L. Li, 1994, “A Mass Spectral Recording and Storing System Based on GPIB Data Transfer for Laser Ionization Time-of-Flight Mass Spectro­metry”, Appl. Spectrosc., 48, 1125‑1131.

    1993

  220. J.Y. Zhang, D.S. Nagra, L. Li, 1993, “Molecular Cooling and Supersonic Jet Formation in Laser Desorption”, Anal. Chem., 65, 2812-2818.
  221. L. Li, A.P.L. Wang, L.D. Coulson, 1993, “Continuous-Flow Matrix-Assisted Laser Desorption Ionization Mass Spectrometry”, Anal. Chem., 65, 493-495.

    1992

  222. D.S. Nagra, J.Y. Zhang, A.P.L. Wang, L. Li, 1992, “Multiphoton Ionization Study of Water and Ammonia Elimination from Dipeptides with Pulsed Rapid Heating and Laser Desorption for Sample Vaporization”, Int. J. Mass Spectrom. Ion Processes, 116, 127‑142.
  223. A.P.L. Wang, L. Li, 1992, “Pulsed Sample Introduction Interface for Combining Flow Injection Analysis with Multiphoton Ionization Time-of-Flight Mass Spectrometry”, Anal. Chem., 64, 769‑775.

    1991

  224. J.Y. Zhang, D.S. Nagra, L. Li, 1991, “Measurement of Gas-Phase Ultraviolet-Visible Absorption Spectra of Thermally Labile Molecules with a Pulsed Rapid Heating Technique for sample Vaporization”, Anal. Chem., 63, 2995‑2999.
  225. J.Y. Zhang, D.S. Nagra, A.P.L. Wang, L. Li, 1991, “On the Capability of Multiphoton Ionization Mass Spectrometry for Isomer Discrimination: Mass Spectra of Positional Isomers of Aromatic Molecules”, Int. J. Mass Spectrom. Ion Processes, 110, 103‑122.
  226. D.S. Nagra. J.Y. Zhang, L. Li, 1991, “Pulsed Rapid Heating Method for Volatilization of Biological Molecules in Multiphoton Ionization Mass Spectrometry”, Anal. Chem., 63, 2188‑2193.
  227. A.P.L. Wang, L. Li, 1991, “A Method for Background Reduction in a Supersonic Jet Multiphoton Ionization Reflectron Time-of-Flight Mass Spectrometer”, Appl. Spectrosc., 45, 969‑976.
  228. L. Li, A.M. Hogg, A.P.L. Wang, J‑Y. Zhang, and D.S. Nagra, 1991, “Pulsed Fast Atom Bombardment Sample Desorption With Multiphoton Ionization in a Supersonic Jet/Reflectron Time-of-Flight Mass Spectrometer”, Anal. Chem., 63, 974‑980.
  229. A.P.L. Wang, J‑Y. Zhang, D.S. Nagra and L. Li, 1991, “Signal Enhancement by Using a Planar Laser Beam for Multiphoton Ionization in a Supersonic Jet/Reflectron Time-of-Flight Mass Spectrometer”, Appl. Spectrosc., 45, 304‑306.

    1990

  230. D.M. Lubman, L. Li, 1990, “Resonant Two-Photon Ionization Spectroscopy of Biological Molecules in Supersonic Jets Volatilized by Pulsed Laser Desorption”, in Lasers and Mass Spectrometry, D.M. Lubman (Ed.), Oxford University Press.

    1989

  231. L. Li, D.M. Lubman, 1989, “R2PI Spectroscopic Analysis of Thin-Layer Chromatography Using Pulsed Laser Desorption/Volatilization Into Supersonic Jet Expansions”, Anal. Chem., 61, 1911.
  232. Lubman, L. Li, T.M. Dunn, 1989, “The 320 nm Electronic Spectrum of Carbazole in a Jet by Two-Photon Ionization”, J. Phys. Chem., 93, 3444.
  233. L. Li, D.M. Lubman, 1989, “Resonant Two-Photon Ionization for Identification of Thermal Decomposition Products in the Laser Desorption of Small Peptides”, Rapid Commun. Mass Spectrom., 3, 12.
  234. L. Li, D.M. Lubman, 1989, “Resonance Enhanced Multiphoton Ionization Spectroscopy and Mass Spectrometry of Tyrosine-Containing Dipeptides Volatilized by Pulsed Laser Desorption Into Supersonic Jets”, Appl. Spectrosc., 43, 543.
  235. L. Li, D.M. Lubman, 1989, “A High Temperature Pulsed Solenoid Valve for Supersonic Jet Introduction Up to 550°C”, Rev. Sci. Instrum., 60, 499.
  236. L. Li, D.M. Lubman, 1989, “Resonance Enhanced Multiphoton Ionization of Nucleosides by Using Pulsed Laser Desorption in Supersonic Beam Mass Spectrometry”, Int. J. Mass Spectrom. Ion Processes, 88, 197.

    1988

  237. L. Li, D.M. Lubman, 1988, “Resonant Two-Photon Ionization Spectroscopic Analysis of Indole and Catechol Derivatives Using Pulsed Laser Desorption with Entrainment Into Supersonic Jet Expansions”, Anal. Chem., 60, 2591.
  238. L. Li, D.M. Lubman, 1988, “Resonant Two-Photon Ionization of Enkephalins and Related Peptides Using Pulsed Laser Desorption in Supersonic Beam Mass Spectrometry”, Anal. Chem., 60, 1409.
  239. L. Li, D.M. Lubman, 1988, “Analytical Jet Spectroscopy of Tyrosine and Its Analogs Using a Pulsed Laser Desorption Volatilization Method”, Appl. Spectrosc., 42, 418.
  240. L. Li, D.M. Lubman, 1988, “Pulsed Laser Desorption Method for Volatilizing Thermally Labile Molecules for Supersonic Jet Spectroscopy”, Rev. Sci. Instrum., 59, 557.
  241. L. Li, D.M. Lubman, 1988, “Resonant Two-Photon Ionization of CBZ‑Derivatized Nonaromatic Peptides Using Pulsed Laser Desorption in Supersonic Beam Mass Spectrometry”, Appl. Spectrosc., 42, 411.

    1987

  242. L. Li, D.M. Lubman, 1987, “UV‑Visible Absorption Spectra of Biological Molecules in the Gas Phase Using Pulsed Laser Desorption in a Diode Array Spectrophotometer”, Anal. Chem., 59, 2538.